Mozzarella Pesto Chicken Grilled Cheese

Featured in: One-Pot Homestyle Comfort Meals

This mouthwatering grilled cheese combines tender shredded chicken breast with vibrant basil pesto and creamy mozzarella, layered between perfectly buttered bread and pan-grilled until golden. The result is a warm, satisfying sandwich with melted cheese and savory flavors that comes together in just 20 minutes.

Perfect for weeknight dinners, lunch prep, or satisfying cravings, this American-Italian fusion sandwich is adaptable to your preferences. Try different breads like ciabatta, add fresh tomato slices or basil leaves, or use rotisserie chicken for convenience. The combination of tender chicken, aromatic pesto, and gooey cheese creates a deeply satisfying meal that pairs wonderfully with crisp beverages.

Updated on Tue, 20 Jan 2026 12:34:00 GMT
Golden, melted mozzarella oozes from a grilled cheese sandwich stuffed with shredded chicken and vibrant green pesto on toasted sourdough bread. Save to Pinterest
Golden, melted mozzarella oozes from a grilled cheese sandwich stuffed with shredded chicken and vibrant green pesto on toasted sourdough bread. | pecanthyme.com

The smell of butter melting into sourdough still stops me in my tracks every single time. I stumbled onto this combination during a particularly exhausting Tuesday when leftover rotisserie chicken was the only thing standing between me and cereal for dinner. Something about the way pesto's bright basil notes cut through rich mozzarella felt like discovering a secret I should have known years ago. Now it is my go-to when I need comfort food that actually feels exciting.

My sister stayed over last month and I made these for lunch, not thinking much of it. She took one bite, went completely silent for a full minute, then asked if I had been secretly taking cooking classes. We ate them standing at the counter because neither of us could wait to sit down properly. Sometimes the best meals are the ones you almost did not bother to make.

Ingredients

  • Sourdough or Italian bread: Sturdy enough to hold everything together without getting soggy, and it develops the most gorgeous golden crust
  • Fresh mozzarella: Skip the pre-shredded stuff and slice it yourself for those incredible melty pockets
  • Unsalted butter: Softened to room temperature so it spreads evenly without tearing the bread
  • Cooked shredded chicken breast: Rotisserie chicken works perfectly here, or use leftovers from a roast
  • Basil pesto: Homemade is wonderful but do not stress about it, a good jarred pesto performs beautifully
  • Optional add-ins: Fresh tomato adds moisture, extra basil keeps things bright, grated Parmesan brings a salty finish

Instructions

Product image
Boil water quickly for tea, coffee, instant soups, and faster prep when cooking grains or noodles.
Check price on Amazon
Prep the foundation:
Lay out your bread slices and spread about one tablespoon of pesto on two of them, going all the way to the edges for maximum flavor in every bite
Build the layers:
Scatter the shredded chicken evenly over the pesto, then arrange mozzarella slices on top, tucking in any tomato or fresh basil if you are using them
Seal the deal:
Top with the remaining bread slices and spread softened butter on the outside of each sandwich, covering both top and bottom completely
Golden perfection:
Cook in a heated skillet over medium heat for three to four minutes per side, pressing gently with your spatula, until the cheese is melty and the bread is deeply golden
The resting moment:
Let the sandwiches rest for a full minute before cutting, which keeps everything from sliding out when you slice
Product image
Boil water quickly for tea, coffee, instant soups, and faster prep when cooking grains or noodles.
Check price on Amazon
A close-up view of a Mozzarella Pesto Chicken Grilled Cheese with a side of sliced tomatoes and fresh basil leaves. Save to Pinterest
A close-up view of a Mozzarella Pesto Chicken Grilled Cheese with a side of sliced tomatoes and fresh basil leaves. | pecanthyme.com

These sandwiches have become my rainy day default, the kind of food that makes a gray afternoon feel deliberate and cozy. I started keeping a jar of pesto in the fridge specifically for those moments when only melty cheese will do.

Bread Choices That Work

Ciabatta creates a wonderfully chewy interior while multigrain adds nuttiness that plays nicely with the basil. I have even used focaccia in a pinch, though the texture gets closer to pizza territory. Whatever you choose, give it a day or two past fresh, slightly stale bread grills up better than anything straight from the bakery bag.

Make It Yours

Swap the chicken for grilled vegetables and you have a vegetarian version that does not feel like a compromise. Zucchini, roasted red peppers, or even thin-sliced eggplant work beautifully. The pesto and mozzarella framework is forgiving enough to support whatever you need to use up or whatever flavors you are craving.

Serving Suggestions

A crisp white wine cuts through the richness, but sparkling water with a lemon wedge is just as refreshing. I like a simple green salad with vinaigrette on the side to balance the heavy, cheesy main. These sandwiches reheat surprisingly well if you use a skillet instead of a microwave, which keeps the bread crisp.

  • Pair with Italian whites like Pinot Grigio if you are having wine
  • Keep the salad light, nothing too creamy or heavy alongside
  • Cut diagonally for easier eating and nicer presentation
Product image
Quickly cook hard boiled, poached, or scrambled eggs and omelets for easy breakfasts and meal prep.
Check price on Amazon
This easy American-Italian fusion sandwich features juicy chicken, gooey mozzarella, and pesto pressed between crispy, golden-buttered bread slices. Save to Pinterest
This easy American-Italian fusion sandwich features juicy chicken, gooey mozzarella, and pesto pressed between crispy, golden-buttered bread slices. | pecanthyme.com

Some recipes are just meant to be eaten with your hands, leaning over the counter, maybe a little cheese on your chin. This is one of those.

Your Questions Answered

Can I prepare this sandwich ahead of time?

You can assemble the sandwich 1-2 hours ahead and refrigerate it before cooking. Bring it to room temperature for 5 minutes before grilling for even cooking and better cheese melt.

What's the best way to get perfectly melted cheese?

Use medium heat and cook for 3-4 minutes per side. Press gently with a spatula to ensure even contact with the pan. If the bread browns too quickly, lower the heat slightly to allow the cheese more time to melt.

Can I use chicken thighs instead of breast?

Yes, chicken thighs work wonderfully and offer more moisture and flavor. Shred cooked thighs the same way as breast meat. The cooking time remains the same since the chicken is already cooked.

What are good alternatives to basil pesto?

Try sun-dried tomato pesto, arugula pesto, or cilantro-lime pesto for different flavor profiles. You can also use freshly made pesto or quality store-bought versions. Adjust the amount based on your pesto preference.

How do I make this sandwich vegetarian?

Replace the chicken with grilled vegetables like zucchini, eggplant, roasted red peppers, or sun-dried tomatoes. You can also add spinach or arugula for extra greens and nutrition while maintaining the same cooking method.

Can I use a panini press instead of a skillet?

Absolutely. A panini press works excellently for this sandwich. Cook for 2-3 minutes until the bread is golden and cheese melts completely. The press provides even heat distribution and doesn't require flipping.

Mozzarella Pesto Chicken Grilled Cheese

Golden grilled cheese sandwich with shredded chicken, pesto, and melted mozzarella. A quick, flavorful fusion of American comfort and Italian taste.

Prep Time
10 min
Time to Cook
10 min
Total Duration
20 min
Author: Ethan Ward


Skill Easy

Cuisine American/Italian Fusion

Portions 2 Portion Size

Dietary Notes None specified

What You'll Need

Bread & Dairy

01 4 slices sourdough or Italian bread
02 4 oz fresh mozzarella, sliced or shredded
03 2 tbsp unsalted butter, softened

Protein

01 1 cup cooked, shredded chicken breast

Sauces & Spreads

01 3 tbsp basil pesto

Optional Add-Ins

01 2 tbsp grated Parmesan cheese
02 1 small tomato, thinly sliced
03 Fresh basil leaves

How to Make It

Step 01

Prepare Bread Foundation: Lay out bread slices and spread 1 to 1.5 tbsp pesto onto two of the slices.

Step 02

Layer Chicken: Evenly distribute shredded chicken on top of the pesto-covered bread slices.

Step 03

Add Cheese and Toppings: Layer mozzarella cheese over the chicken. Add tomato slices and fresh basil if using. Sprinkle with Parmesan for extra flavor if desired.

Step 04

Assemble Sandwiches: Top with remaining bread slices to form sandwiches.

Step 05

Butter Exterior: Spread softened butter on the outsides of each sandwich, coating both top and bottom surfaces.

Step 06

Cook to Golden Perfection: Heat a large skillet or grill pan over medium heat. Place sandwiches in the skillet, pressing slightly with a spatula. Cook for 3 to 4 minutes per side until bread is golden brown and cheese is melted.

Step 07

Rest and Serve: Remove from skillet, let rest for 1 minute, then cut in half and serve warm.

What You'll Need

  • Skillet or grill pan
  • Spatula
  • Knife
  • Cutting board

Allergy Details

Please check every ingredient for allergens and talk to a healthcare provider with any concerns.
  • Contains dairy: mozzarella, butter, Parmesan
  • Contains wheat and gluten from bread
  • May contain tree nuts if pesto contains pine nuts
  • Store-bought pesto may contain nut and cheese allergens; check label carefully

Nutrition Details (each serving)

Nutritional info is for reference and doesn't replace a professional's advice.
  • Caloric Value: 520
  • Total Fat: 27 g
  • Carbohydrates: 32 g
  • Proteins: 36 g